Continuous Oxygen Diffusion (CDO) Therapy Used in the Context of Low Carbohydrate Nutritional
Advice and Comprehensive Wound Healing Approaches – A Retrospective Chart Review Introduction Wound healing is a complex physiological process that involves a series of
coordinated events. Oxygen and insulin play critical roles in this process,
influencing various cellular and molecular mechanisms that facilitate tissue
repair.
Oxygen supports metabolism and energy production, crucial for cell
proliferation and collagen synthesis. Adequate oxygenation enhances
fibroblast and keratinocyte function, essential for tissue regeneration, while
hypoxia impairs healing.
Insulin, equally critical, promotes glucose uptake, providing energy for cellular
repair activities. Its anabolic effects stimulate protein synthesis and cell
proliferation. Research in diabetic patients highlights that impaired insulin
signaling leads to chronic wounds due to reduced cellular responsiveness and
energy availability.
The interplay between oxygen and insulin resistance improvement in wound
healing is particularly evident in diabetic patients. In such cases, both oxygen
deficiency and insulin resistance contribute to delayed healing. Hyperglycemia
and hyperinsulinemia are often the core causes of numerous problems in
diabetic individuals. Research indicates that combining insulin sensitivity
approaches with strategies to improve tissue oxygenation can synergistically
promote wound closure and reduce healing time. The delayed wound healing,
hypoxia and hyperglycemia patient evaluated and left foot connection relevant
for diabetics and non-diabetic individuals
Methods Patients of varying ages, wound durations, and
etiologies were reviewed from 2022 to March 2025.
Preliminary data show a strong correlation between
CDO therapy using the OxyGeni® System (EO2
Concepts, San Antonio, TX) and improved granulation,
healing, and glycemic control in 13 of 15 patients. Two
patients had a very short CDO duration and were not
evaluable. All patients, including non-diabetics, who
received CDO therapy were analyzed. Results This retrospective study examines wound healing in 15 patients using CDO
therapy. Among them, 13 showed significant improvements – 8 non-diabetic
and 5 diabetic – in granulation and healing. Sharp debridement and
comprehensive wound care, particularly low-carbohydrate, high-protein
nutritional guidance to improve insulin sensitivity, were standard treatments.
Three cases are highlighted here to demonstrate typical results that we’ve
experienced in our clinic.